Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E.
نویسندگان
چکیده
منابع مشابه
Constrained patterns of covariation and clustering of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations
OBJECTIVES We characterized pairwise and higher order patterns of non-nucleoside reverse transcriptase inhibitor (NNRTI)-selected mutations because multiple mutations are usually required for clinically significant resistance to second-generation NNRTIs. PATIENTS AND METHODS We analysed viruses from 13 039 individuals with sequences containing at least one of 52 published NNRTI-selected mutat...
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(NNRTIs) are promising drugs for the treatment of HIV when used in combination with other antiHIV drugs such as nucleoside reverse transcriptase (RT) inhibitors and protease inhibitors. The first generation of NNRTIs have, however, suffered from the rapid development of resistance. This review discusses the properties of the FDAapproved NNRTI drugs and focuses on the recent efforts being made t...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1993
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)53227-0